The Phosphatase CSW Controls Life Span by Insulin Signaling and Metabolism Throughout Adult Life in Drosophila
نویسندگان
چکیده
منابع مشابه
Childhood Self-Control and Unemployment Throughout the Life Span
Psychological Science manuscript #: PSCI-140209.R3 Corresponding author: Dr. Michael Daly Articles accepted to Psychological Science after January 1, 2014, are eligible to earn badges that recognize open scientific practices: publicly available data, material, or preregistered research plans. Please read more about the badges on our Open Practices page, and you can also find information in the ...
متن کاملLife span extension by targeting a link between metabolism and histone acetylation in Drosophila
Old age is associated with a progressive decline of mitochondrial function and changes in nuclear chromatin. However, little is known about how metabolic activity and epigenetic modifications change as organisms reach their midlife. Here, we assessed how cellular metabolism and protein acetylation change during early aging in Drosophila melanogaster. Contrary to common assumptions, we find that...
متن کاملInfluence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling
Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormones known as dafachronic acids (DAs) influence longevity by binding to and regulating the activity of the conserved nuclear receptor DAF-12, and the insulin receptor (InsR) ortholog DAF-2 contro...
متن کاملExtension of life span of Drosophila melanogaster by the inhibitors of tryptophan-kynurenine metabolism.
Upregulation of kynurenine (KYN) formation from tryptophan (TRY) was associated with aging in animal and human studies. TRY - KYN metabolism is affected by the activities of TRY 2,3-dioxygenase 2 (TDO) and ATP-binding cassette (ABC) transporter regulating TRY access to intracellular TDO. We studied the effects of TDO inhibitor, alpha-methyl tryptophan (aMT), and ABC transported inhibitor, 5-met...
متن کاملFood restriction differentially affects pituitary hormone mRNAs throughout the adult life span of male F344 rats.
Because neuroendocrine mechanisms may contribute to the antiaging effects of food restriction (FR), we measured the effect of FR on mRNAs encoding anterior pituitary (AP) tropic hormones. Slot blots or RNase protection assays were done on AP RNA from 3-, 6-, 12-, 18- and 24-mo-old male F344 rats consuming food ad libitum (AL) or food restricted (FR; to 60% of AL food intake) from 6 wk. Both AL ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2020
ISSN: 1664-8021
DOI: 10.3389/fgene.2020.00364